منابع مشابه
Genomics of human longevity
In animal models, single-gene mutations in genes involved in insulin/IGF and target of rapamycin signalling pathways extend lifespan to a considerable extent. The genetic, genomic and epigenetic influences on human longevity are expected to be much more complex. Strikingly however, beneficial metabolic and cellular features of long-lived families resemble those in animals for whom the lifespan ...
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Are there limits to human longevity? We suggest a new demographic model to describe human demographic trajectories. Specifically, the model mathematically defines the limits of longevity. Through the demographic analysis of trends for Sweden (between 1751 and 2002), Switzerland (between 1876 and 2002) and Japan (between 1950 and 1999), which are the longest-lived countries, we would like to dem...
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Seeking to locate changes in longevity in hominin evolution, Caspari and Lee (2004) calculated a ratio of old to young adult dentitions in assemblages of fossil taxa. They found an especially large difference in this ratio between Neandertals and Upper Paleolithic modern humans. While the important question they addressed can only be answered with fossil evidence, their ratio, as we show here, ...
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With the rapid proliferation of user-generated content available on the Internet, one of the biggest challenges is determining the relevancy of the information shown. The content often comes in two camps: ephemeral or evergreen. Evergreen content such as recipes for carrot cake or intro to data structures frequently don’t change with time, whereas ephemeral content, such as celebrity hot or not...
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In recent we introduced, developed and established a new concept, model, methodology and principle for studying human longevity in terms of demographic basis. We call the new model the " Weon model " , which is a general model modified from the Weibull model with an age-dependent shape parameter to describe human survival and mortality curves. We demonstrate the application of the Weon model to...
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ژورنال
عنوان ژورنال: Science
سال: 2002
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.292.5522.1654